Passage 4:
Probably the most famous case of hemophilia is often called Royal hemophilia. In this case, Queen Victoria of England, who lived from 1819-1901, was a carrier of the mutating factor 8 that leads to hemophilia type A. Queen Victoria may have inherited the mutated gene from one of her parents, though there is no sign of the mutated gene in the families of Victoria’s parents up to that time that she was born. The mutated factor 8 may also have mutated spontaneously in Victoria, as seems to happen sometimes.
However Victoria came to be a carrier of the gene with the mutated factor, she unfortunately passed it on to some of her children. She had nine children, and three of them, her daughters Alice and Beatrice and her son Leopold, received the mutated gene from their mother. Victoria’s daughters then intermarried with other royal houses of Europe and carried the disease with them. Through Queen Victoria’s daughter Beatrice, the disease was carried into the royal family of Spain. Through Queen Victoria’s daughter Alice, the disease was introduced into the royal families of Austria and Russia, though the disease no longer exists in the Russian family because Victoria’s granddaughter Alexandra and her children were all killed during the Russian revolution.
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